A common question I hear from clients who are considering or already on testosterone replacement therapy (TRT) is: "Does TRT cause cardiovascular disease?" Naturally, this is a major concern—after all, undergoing a treatment that aims to improve your health shouldn't come with an increased risk of heart attack or other cardiovascular events.
Fortunately, a recent study published in the New England Journal of Medicine on June 16, 2023, sheds light on this concern. The study, titled "Cardiovascular Safety of Testosterone-Replacement Therapy," found no significant link between TRT and an increased risk of cardiovascular incidents.
Key Findings from the Study
The study included 5,204 men aged 45 to 80, all of whom had existing cardiovascular disease or risk factors for it. This was a double-blind study, meaning neither the participants nor the medical personnel knew whether a particular individual was receiving testosterone or a placebo.
The participants were treated with testosterone gel, and here’s what the study found:
The average treatment duration was about 21.7 months, with a follow-up period averaging 33 months.
A primary cardiovascular event occurred in 7.0% of men in the testosterone group, compared to 7.3% in the placebo group.
This shows that there was no significant difference in cardiovascular events between the men receiving testosterone and those receiving a placebo.
Additional Benefits of TRT
The study also highlighted several other benefits of testosterone therapy:
Improved sexual function
Increased bone mineral density
Correction of unexplained anemia
Moderate reduction in depressive symptoms
However, due to uncertainty about cardiovascular outcomes, many clinicians and patients have hesitated to use testosterone therapy, especially since testosterone deficiency is not a life-threatening condition. This study's findings on cardiovascular safety may help patients and doctors make more informed decisions regarding the benefits and risks of TRT for middle-aged and older men with low testosterone (hypogonadism).
Conclusion
The study shows that TRT does not increase the risk of cardiovascular events. However, if you're considering starting TRT, it's essential to consult with a qualified TRT provider.
At Optimal Man, we focus on symptom improvement and finding the optimal testosterone level for you, rather than aiming for a specific number. Our goal is to help you feel your best by closely monitoring your progress and conducting regular lab work to ensure all hormones and other levels are where they should be. To learn more or to start your journey toward feeling your best, contact Optimal Man today and schedule your free consultation.
For more information on the study, you can read the full article here.
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